This action drama features John Wayne in an early, non western role. He plays a trucker who owns half of a small but increasingly successful trucking firm. When Duke's company begins stealing business away from LeRoy Mason's firm, Mason retaliates by engineering the violent death of Wayne's partner, Emerson Treacy. He falls in love with the head of the railroad shipping department. Unfortunately, the evil competitor murders the Duke's partner in a mysterious explosion. The Big Guy then joins forces with an even larger company and destroys Mason's business causing Mason to team up with a train magnate and plot his revenge. The film's highlight, is a cross country race between Duke's trucks and Mason's trains.