Yet another tuneful Roy Rogers Western named after a song, The Cowboy and the Senorita features Roy and sidekick Teddy Bear (Guinn "Big Boy" Williams) as a couple of would-be prospectors fired from a small town café when the latter gets in trouble with an irate customer (rotund Ferdinand Munier). At the nearby town of Bonanza, the two friends find themselves falsely accused of kidnapping young Chip Williams (Mary Lee), who is actually a runaway. Having befriended both her girl and her half-sister Isabel Martinez (Dale Evans), Roy and Teddy Bear manage to solve the riddle of a treasure hidden in a supposedly worthless mine despite the sabotaging efforts of smooth tycoon Craig Allen (John Hubbard). In between the Western shenanigans, Rogers joins Lee, Evans, the Sons of the Pioneers, and such guest artists as the dance team of Jane Beebe and Ben Rochelle in no less than five musical numbers, including the title tune and a delightful rendition of Ned Washington and Phil Ohman's "What'll I Use for Money." Spanky McFarland, of Our Gang fame, has a funny silent bit in the opening scene.