Down-and-out artist Joe Manning (John Bromfield) wakes up from a night of drunken revelry in a jail cell, where he's being held on suspicion for the murder of a nightclub singer. It so happens that the dead woman was clutching a "class of 1945" high school pin in her hand, and it was on the basis of this circumstantial evidence that Joe was incarcerated. Provided with a phony alibi by friendly carhop Slacks (Julie London), Joe sets about to find the real killer--all the while hoping that it isn't himself. Since there are quite a few 1945 alumni in the neighborhood, Joe really has his work cut out for him. Featured in the supporting cast of Crime Against Joe is corpulent Henry Calvin, the future "Sergeant Garcia" on TV's Zorro, as Joe's cabdriver buddy.