Music, gangster melodrama, and snappy newspaper comedy is blended into the usual Western shenanigans in this unusual Gene Autry vehicle filmed on-location at the Russell Ranch near Agoura Hills, CA. Autry, as always, plays himself, a singing star, with Smiley Burnette and Joe Strauch Jr. as sidekicks Frog and Tadpole Millhouse. The trio is visiting Pop Harrison's (Forrest Taylor) Wyoming dude ranch, where Pop's wastrel son, Tex (James Seay), is in trouble with the law. Tex is involved with one Mr. Crowley (George Gordon), who really a gangster named Luigi. Recognized by newspaper reporters Clem (Fay McKenzie) and Hack (Chick Chandler), Crowley and his men indulges in a bit of skullduggery and are the obvious suspects when Pop Harrison is shot. But as Gene discovers, the gangsters are merely red herrings, the real culprit being a person much closer to home. In between detective work and romancing the girl reporter, Autry finds time enough to warble six songs, including Irving Berlin's then very topical "Any Bonds Today?," the official anthem of U.S. Defense Bond campaign. Despite good performances by Fay McKenzie, the daughter of veteran B-Western personality Robert McKenzie, and the always welcome Chick Chandler, Home in Wyomin' was not wholly appreciated by Autry's legion of fans who wanted their star straight up.