Bumbling saber-toothed squirrel Scrat continues to cause mischief in outer space, where he sets off a series of events that send an asteroid hurtling toward Earth. Soon, Manny the woolly mammoth (voiced by Ray Romano), Sid the sloth (John Leguizamo), and Diego the saber-toothed tiger (Denis Leary) embark on a journey with their rambunctious animal friends to prevent the asteroid from ending life as they know it. Simon Pegg, Queen Latifah, Adam DeVine, Nick Offerman, and Jennifer Lopez also lend their voices to this animated sequel.