Lyle Talbot stars as "Three Star" Halsey, a hotshot West Coast aviator with a reputation for recklessness. Time and time again, Halsey promises his stewardess sweetheart Judy Wagner (Ann Dvorak) that he'll stop taking risks, and time and again he breaks his word. After several misadventures, Halsey becomes a hero when he prevents a top-secret explosive formula from falling into the hands of the villains -- and as a bonus, solves four airborne murders. Much of the aerial photography in Murder in the Clouds would be reused in such future Warners programmers as Fly-Away Baby and Fugitive in the Sky.