The titular girl is Lupe Velez, a tempestuous cabaret entertainer. Donald Woods plays a staid American ad man who hires her for a New York nightclub. Woods is engaged to be married, but secretly harbors affection for Velez. The volatile Ms. Velez is less subtle, and actively campaigns for the affections of Woods, with the help of Donald's lovably larcenous Uncle Matt (Leon Errol). Though not intended as such, Girl From Mexico was the first of RKO's eight-film "Mexican Spitfire" series. The role of the Spitfire's husband was played by several different actors, but Lupe Velez and Leon Errol remained with the series throughout its four-year run.