Men of Chance refers to those well-dressed gentlemen who stake their fortunes upon the outcome of horse races. Ricardo Cortez plays Diamond Johnny Silk, a big-time gambler whose rough exterior hides the fact that he's scrupulously honest. Johnny's enemies, led by smooth but disreputable Dorval (John Halliday), dispatch seductress Marthe (Mary Astor) to convince our hero to poison his own horse before the upcoming Big Race. Instead, Astor falls in love with Johnny and marries him, resulting in disaster for Dorval and his stooges. Men of Chance was based on a story by Louis Weitzenkorn, of Five Star Final fame.