Another of RKO's movie vehicles for radio comic Joe Penner ("You na-a-a-asty man!"), Mr. Doodle Kicks Off stars Penner as the son of a wealthy and influential businessman. Penner's dad is disappointed at how sonny has turned out (we can't blame him), but is bound and determined to enroll Joe in his alma mater and turn him into a college football hero. Penner falls for June Travis, daughter of the college president, and sets his mind (what there is of it) to make good. Incredibly, Joe makes it into the Big Game, where he pulls a "Roy Riegels" and runs the wrong way. The best moment in Mr. Doodle Kicks Off, if indeed there is one, features Joe Penner conducting a college orchestra while strapped in a straitjacket.