A woman is torn between a comfortable lie and the painful truth in this drama. After she is abandoned by her unfaithful boyfriend Stephen Morely (Lyle Bettger), Helen Ferguson (Barbara Stanwyck) discovers that she's pregnant, and she has no choice but to go home to her family. Shortly after boarding the train, Helen meets Hugh and Patrice Harkness (Richard Denning and Phyllis Thaxter), a recently married couple who are travelling to visit Hugh's parents, who have yet to met his bride. Patrice, who is also with child, strikes up a conversation with Helen, and allows her to try on her beautiful wedding ring. Moments later, the train becomes involved in a terrible accident in which Hugh and Patrice are killed; because she was still wearing Patrice's ring, Helen is mistaken for the late Mrs. Harkness by Hugh's parents (Jane Cowl and Henry O'Neill), and is taken home with them as she recovers and has her baby. Helen begins to feel a part of the family until Stephen arrives, demanding money to keep her true identity a secret. No Man of Her Own was remade in 1996 as the comedy Mrs. Winterbourne.